Precise physical measurements are important for cells to understand molecular mechanisms occurred in cells as well as for solid state materials. However, in vivo measurements are difficult because intracellular environments are complex non-equilibrium states, in which theories of statistical physics are often violated.

In our lab, we develop techniques to precisely measure physical quantities such as force, velocity and energy for proteins and organelle inside cells, based on fluorescence microscopy. We think development of analytical methods (software) using statistical physics, information science and mathematics as well as development of microscopes (hardware). We aim to understand cellular phenomena quantitatively by constructing theoretical models using the measured physical quantities.

We hope such theories can contribute to the understanding of neurological disorders particularly.